Dr. S. Rajasubramaniam

Scientist 'D'

rajasubamaniam@rmrct.org, raja.rmrct@gmail.com

 

                  Date of Joining ICMR                  :                                  01.11.2010

                  Date of Joining Current position    :                                 01.11.2010

                 Discipline                                      :                                 Biotechnology & Molecular Biology

                 Educational Qualification               :                                 Ph.D.

                 Research Experience                     :                                 15 years

                Awards/Fellowship                      :  

  •            Post-Doctoral Fellowship, School of Medicine , Indiana University, Indianapolis , USA

  •            Qualified UGC - CSIR  JRF-NET Examination

  •            CSIR – Research Associate Fellowship

  •  Best Poster in Translational Research in Post-Doctoral and Clinical Fellows category in the Year  2006 at  Cancer Research   Day, Indiana University, Indianapolis, USA.

 

                Foreign Visits                            :                                  United States of America

               Teaching experience                   :

  • Guest lecturer, Department of Biosciences, Jamia Millia Islamia, New Delhi . Courses: Genome biology and Molecular Biology for M.Sc Biosciences and M. Sc. Biotechnology. January 2002 – October 2003.

 

  • Counsellor Indira Gandhi National Open University, Jesus & Mary College study center, New Delhi . Courses: (1) Foundation course in Science and Technology, (2) Applied course in Human Environment and (3) Applied course in Nutrition.  September 1994 - October 2003.

             Publications:

  • Rajasubramaniam Shanmugam, Praveen Kusumanchi, Liang Cheng, Sundar Neelakantan, Peter Crooks, William Matthews, Harikrishna Nakshatri, and Christopher J Sweeney (2010).  A water soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting  NF-κB and generating reactive oxygen species.  Prostate. 70:1074-1086.

  • Rajasubramaniam Shanmugam, Praveen Kusumanchi, Liang Cheng, Peter Crooks, Sundar Neelakantan, Tyler Peat, James Klaunig, William Matthews, Harikrishna Nakshatri, Christopher J Sweeney (2010). A water soluble parthenolide analogue suppresses in vivo tumor growth of two tobacco associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species. International Journal of Cancer (Accepted & available online).

  • Noah M. Hahn, Robin T. Zon, Menggang Yu, Foluso Ademuyiwa, Thomas Jones, William Dugan, Charles Whalen, Rajasubramaniam Shanmugam, Todd Skaar, Christopher J. Sweeney (2009). A Multicenter Phase II Study of Pemetrexed as Second-Line Chemotherapy for the Treatment of Metastatic Castrate Resistant Prostate Cancer (CRPC); Hoosier Oncology Group GU03-67.  Annals of Oncology.20(12):1971-6.

  • Ganesan U, Suri SS, Rajasubramaniam S, Rajam MV, Dasgupta I (2009). Transgenic expression of coat protein gene of Rice tungro bacilliform virus in rice reduces the accumulation of viral DNA in inoculated plants. Virus Genes. 39(1):113-9.

  • Tyagi H, Rajasubramaniam S, Rajam MV, Dasgupta I (2008). RNA-interference in rice against Rice tungro bacilliform virus results in its decreased accumulation in inoculated rice plants. Transgenic Research  17(5):897-904.

  • Attaya Suvannasankha, Colin D. Crean, Rajasubramaniam S, Sherif S. Farag, Rafat Abonour, H. Scott Bosewell and Harikrishna Nakshatri (2008). Antimyeloma Effects of a Sesquiterpene Lactone Parthenolide; Overcoming Drug Resistance and Ameliorating the Protective Effects of the Bone Marrow Microenvironment. Clinical Cancer Research 14(6): 1814-1822.

  • Bryan Holocomb, Michele T Yip-schneider, Jesus M Matos, Jennifer Dixon, Jason Kennard, Julie Mahomed, Rajasubramaniam Shanmugam, Judith Sebolt-Leopold and C Max Schmidt (2008). Pancreatic cancer cell genetics and signalling response to treatment correlate with efficacy of gemcitabine-based molecular targeting strategies. Journal of Gastrointestinal Surgery 12(2): 288-96.

  • Himani Tyagi, S. Rajasubramaniam and Indranil Dasgupta (2007). Regeneration and agrobacterium-mediated transformation of a popular indica rice variety, ADT39. Current Science 93(5): 678-683.

  • Rajasubramaniam S, Vetrichelvan Jayaprakasan, Yesim Gokmen-Polar, Stephanie Kelich, Kathy D Miller, Michele Yip-Schneider, Liang Cheng, Poornima Bhat-Nakshatri, George W Sledge, Harikrishna Nakshatri, Michael A. Miller, Timothy DeGrado, Gary D. Hutchins  and Christopher J Sweeney (2006) Restoring chemotherapy and hormone therapy sensitivity by parthenolide in a xenograft hormone refractory prostate cancer model.  Prostate 66(14):1498-511.

  • Patil BL, Rajasubramaniam S, Bagchi C and Dasgupta I (2005). Both Indian cassava mosaic virus and Sri Lankan cassava mosaic virus are found in India and exhibit high variability as assessed by PCR-RFLP. Archives of Virology 150(2): 389-397.

  • Christopher J Sweeney, Lang Li, Rajasubramaniam S, Poornima Bhat-Nakshatri, Vetrichelvan Jayaprakasan, Lee Ann Baldridge, Thomas Gardner, Martin Smith, Harikrishna Nakshatri and Liang Cheng (2004). Nuclear Factor-ĸB is Constitutively Activated in Prostate cancer in vitro and is Overexpressed in Prostatic Interaepithelial Neoplasia and Adenocarcinoma of the Prostate. Clinical Cancer Research 10: 5501-5507.

  • Rajasubramaniam S and Pardha Saradhi P. (1997) Rapid multiplication of Phyllanthus fraternus ; A plant with anti-hepatitis virus activity. Industrial Crops and Products (Elsevier) 6: 35-40.

  • Rajasubramaniam S and Pardha Saradhi P (1994). Organic nitrogen stimulates caulogenesis from hypocotyls callus of Phyllanthus fraternus. Plant Cell Reports 13: 619-622.

 

            Membership of Societies:

 

  • Associate Member, American Association for Cancer Research ( USA ).

  • Life member, Indian Society for Medicinal and Aromatic Plants. (ISMAP)